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Miransertib

CAS No. 1313881-70-7

Miransertib ( ARQ-092 )

Catalog No. M11258 CAS No. 1313881-70-7

Miransertib (ARQ-092) is a potent, selective and allosteric inhibitor of Akt1/2/3 with IC50 of 5/4.5/16 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 327 In Stock
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Biological Information

  • Product Name
    Miransertib
  • Note
    Research use only, not for human use.
  • Brief Description
    Miransertib (ARQ-092) is a potent, selective and allosteric inhibitor of Akt1/2/3 with IC50 of 5/4.5/16 nM respectively.
  • Description
    Miransertib (ARQ-092) is a potent, selective and allosteric inhibitor of Akt1/2/3 with IC50 of 5/4.5/16 nM respectively; inhibits cellular AKT activation and the phosphorylation of the downstream target PRAS40; inhibits tumor growth in a human xenograft mouse model of endometrial adenocarcinoma; orally bioavailable.Blood Cancer Phase 1 Clinical
  • Synonyms
    ARQ-092
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1313881-70-7
  • Formula Weight
    432.52
  • Molecular Formula
    C27H24N6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 40.2 mg/mL
  • SMILES
    C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
  • Chemical Name
    2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lapierre JM, et al. J Med Chem. 2016 Jul 14;59(13):6455-69.
2. Kim K, et al. Haematologica. 2017 Feb;102(2):246-259.
3. Roth GS, et al. Mol Cancer Ther. 2017 May 31. pii: molcanther.0602.2016.
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