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Miransertib
CAS No. 1313881-70-7
Miransertib ( ARQ-092 )
Catalog No. M11258 CAS No. 1313881-70-7
Miransertib (ARQ-092) is a potent, selective and allosteric inhibitor of Akt1/2/3 with IC50 of 5/4.5/16 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 88 | In Stock |
|
| 10MG | 155 | In Stock |
|
| 25MG | 327 | In Stock |
|
| 50MG | 537 | In Stock |
|
| 100MG | 860 | In Stock |
|
| 500MG | 1701 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMiransertib
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NoteResearch use only, not for human use.
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Brief DescriptionMiransertib (ARQ-092) is a potent, selective and allosteric inhibitor of Akt1/2/3 with IC50 of 5/4.5/16 nM respectively.
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DescriptionMiransertib (ARQ-092) is a potent, selective and allosteric inhibitor of Akt1/2/3 with IC50 of 5/4.5/16 nM respectively; inhibits cellular AKT activation and the phosphorylation of the downstream target PRAS40; inhibits tumor growth in a human xenograft mouse model of endometrial adenocarcinoma; orally bioavailable.Blood Cancer Phase 1 Clinical
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SynonymsARQ-092
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1313881-70-7
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Formula Weight432.52
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Molecular FormulaC27H24N6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 40.2 mg/mL
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SMILESC1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
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Chemical Name2-Pyridinamine, 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lapierre JM, et al. J Med Chem. 2016 Jul 14;59(13):6455-69.
2. Kim K, et al. Haematologica. 2017 Feb;102(2):246-259.
3. Roth GS, et al. Mol Cancer Ther. 2017 May 31. pii: molcanther.0602.2016.
2. Kim K, et al. Haematologica. 2017 Feb;102(2):246-259.
3. Roth GS, et al. Mol Cancer Ther. 2017 May 31. pii: molcanther.0602.2016.
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