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GSK-690693
CAS No. 937174-76-0
GSK-690693 ( GSK 690693;GSK690693 )
Catalog No. M16713 CAS No. 937174-76-0
A potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
|
| 10MG | 124 | In Stock |
|
| 25MG | 251 | In Stock |
|
| 50MG | 402 | In Stock |
|
| 100MG | 593 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK-690693
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
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DescriptionA potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively; also inhibits additional members of the AGC kinase family (PKA, PrkX, and PKC isozymes, IC50s<100 nM); dose-dependently reduces the phosphorylation GSK3 beta, PRAS40 and Forkhead, inhibits proliferation and induces apoptosis in a subset of tumor cells; exhibits significant antitumor activity in mice model.Blood Cancer Phase 1 Discontinued
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SynonymsGSK 690693;GSK690693
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt1;Akt3;PKCη;PKCθ;PrkX
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number937174-76-0
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Formula Weight425.48
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Molecular FormulaC21H27N7O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(O)(C)C#CC1=NC=C(OC[C@@H]2CNCCC2)C3=C1N=C(C4=NON=C4N)N3CC
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Chemical Name3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Heerding DA, et al. J Med Chem. 2008 Sep 25;51(18):5663-79.
2. Rhodes N, et al. Cancer Res. 2008 Apr 1;68(7):2366-74.
3. Levy DS, et al. Blood. 2009 Feb 19;113(8):1723-9.
2. Rhodes N, et al. Cancer Res. 2008 Apr 1;68(7):2366-74.
3. Levy DS, et al. Blood. 2009 Feb 19;113(8):1723-9.
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