
Methylisoindigotin
CAS No. 97207-47-1
Methylisoindigotin( Methylisoindigotin )
Catalog No. M16877 CAS No. 97207-47-1
Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
Purity : >98% (HPLC)






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25MG | 160 | In Stock |
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50MG | 245 | In Stock |
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100MG | 385 | In Stock |
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Biological Information
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Product NameMethylisoindigotin
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NoteResearch use only, not for human use.
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Brief DescriptionMeisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
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DescriptionMeisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).(In Vitro):Meisoindigo (Dian III; 5-20 μM; for 24?hours) inhibits growth of the AML cell lines.Meisoindigo (10?μM; for 24?hours) induces apoptosis of acute myeloid leukemia.Meisoindigo (5-10?μM; for 24?hours) causes cell-cycle arrest.Meisoindigo (5-10?μM; for 24?hours) increases the cleaved caspase-3 and pro-apoptotic Bak, and decreases Bcl-2 and Bcl-xL levels in HL-60 cells.Meisoindigo (10, 30, 50, 100, 150 μM; 24 hours) interdicts LPS-induced (1 μg/mL) NLRP3 inflammasome activation and M1/M2 polarization through down-regulation of TLR4 pathways after OGD/R in HT-22 and BV2 cells.(In Vivo):Meisoindigo (Dian III; 50-150?mg/kg; IP; daily; for 14 days) has anti-leukemic activity in?vivo.Meisoindigo (2, 4, 8, 12 mg/kg; IP; before MCAO and 2 h after reperfusion) significantly reduces infarct volume, ameliorates neurological deficits 3 days after middle cerebral artery occlusion (MCAO) in Wild-type C57BL/6J mice (25-30 g). Meisoindigo reduces edema and lowers AQP4 expression in the brain.
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In VitroMeisoindigo (Dian III; 5-20 μM; for 24?hours) inhibits growth of the AML cell lines. Meisoindigo (10?μM; for 24?hours) induces apoptosis of acute myeloid leukemia. Meisoindigo (5-10?μM; for 24?hours) causes cell-cycle arrest. Meisoindigo (5-10?μM; for 24?hours) increases the cleaved caspase-3 and pro-apoptotic Bak, and decreases Bcl-2 and Bcl-xL levels in HL-60 cells. Meisoindigo (10, 30, 50, 100, 150 μM; 24 hours) interdicts LPS-induced (1 μg/mL) NLRP3 inflammasome activation and M1/M2 polarization through down-regulation of TLR4 pathways after OGD/R in HT-22 and BV2 cells. Cell Viability Assay Cell Line:HL-60, NB4, U937 leukemic cell lines Concentration:5, 10, 15, 20 μM Incubation Time:For 24?hours Result:Inhibited growth of the AML cell lines in a dose- and time-dependent manner.Apoptosis Analysis Cell Line:HL-60 cells Concentration:10?μM Incubation Time:For 24?hours Result:Induced apoptosis of acute myeloid leukemia.Cell Cycle Analysis Cell Line:HL-60 cells Concentration:5, 10?μM Incubation Time:For 24?hours Result:Caused cell-cycle arrest, with more cells in sub-G1 and G0/G1 phases and fewer cells in the S phase, in a dose-dependent manner.Western Blot Analysis Cell Line:HL-60 cells Concentration:5, 10?μM Incubation Time:For 24?hours Result:Increased the cleaved caspase-3 and pro-apoptotic Bak, and decreased Bcl-2 and Bcl-xL levels in HL-60 cells.
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In VivoMeisoindigo (Dian III; 50-150?mg/kg; IP; daily; for 14 days) has anti-leukemic activity in?vivo. Meisoindigo (2, 4, 8, 12 mg/kg; IP; before MCAO and 2 h after reperfusion) significantly reduces infarct volume, ameliorates neurological deficits 3 days after middle cerebral artery occlusion (MCAO) in Wild-type C57BL/6J mice (25-30 g). Meisoindigo reduces edema and lowers AQP4 expression in the brain. Animal Model:NOD/SCID mice, 6-8 weeks old, with HL-60 leukemic cellsDosage:50, 100, 150?mg/kg Administration:IP; daily; for 14 days Result:Had anti-leukemic activity in?vivo.
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SynonymsMethylisoindigotin
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis inducer
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number97207-47-1
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Formula Weight276.29
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Molecular FormulaC17H12N2O2
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCN(C1=CC=CC=C1/C2=C3C(NC4=C\3C=CC=C4)=O)C2=O
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Chemical Name(E)-1,1'-dimethyl-[3,3'-biindolinylidene]-2,2'-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee CC, et al. Leuk Lymphoma. 2010 May;51(5):897-905.
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