Sophoraflavanone G( Kushenol F | Vexibinol )

Catalog No. M21472 CAS No. 97938-30-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Sophoraflavanone G
Note

Research use only, not for human use.
Brief Description

Sophoraflavanone G (Kushenol F) isolated from Sophora flavescens induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
Description

Sophoraflavanone G (Kushenol F) isolated from Sophora flavescens induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
In Vitro

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells?in a dose-dependent manner.Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome?c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathwaySophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of29.7 ± 5.2μM.
In Vivo

——
Synonyms

Kushenol F | Vexibinol
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

——

CAS Number

97938-30-2
Formula Weight

424.5
Molecular Formula

C25H28O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (588.94 mM)
SMILES

CC(C)=CC[C@H](Cc(c(O[C@@H](CC1=O)c(ccc(O)c2)c2O)c1c(O)c1)c1O)C(C)=C
Chemical Name

4H-1-Benzopyran-4-one 23-dihydro-57-dihydroxy-2-(24-dihydroxyphenyl)-8-(5-methyl-2-(1-methylethenyl)-4-hexenyl)- (S-(R*S*))-

1.Li ZY et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76.

Calculator

molnova catalog