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Merck60

CAS No. 849234-64-6

Merck60 ( BRD 6929;Compound-60 )

Catalog No. M16166 CAS No. 849234-64-6

Merck60 (BRD 6929, Compound-60)is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Merck60
  • Note
    Research use only, not for human use.
  • Brief Description
    Merck60 (BRD 6929, Compound-60)is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively.
  • Description
    Merck60 (BRD 6929, Compound-60)is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively; displays 50-400 fold selectivity over class I HDAC3 (IC50=458 nM) and no appreciable inhibition of HDAC8 or of the class II HDACs (IC50>30 uM); alters gene expression in brain circuits involved in mood regulation, improves mood-related behaviors in mice.
  • Synonyms
    BRD 6929;Compound-60
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    849234-64-6
  • Formula Weight
    351.42
  • Molecular Formula
    C19H17N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schroeder FA, et al. PLoS One. 2013 Aug 14;8(8):e71323.
2. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
3. Stubbs MC, et al. Clin Cancer Res. 2015 May 15;21(10):2348-58.
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