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LMK-235

CAS No. 1418033-25-6

LMK-235 ( LMK 235;LMK 235 )

Catalog No. M11747 CAS No. 1418033-25-6

A selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
5MG	41	In Stock
10MG	65	In Stock
25MG	128	In Stock
50MG	222	In Stock
100MG	402	In Stock
200MG	593	In Stock
500MG	888	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

LMK-235
Note

Research use only, not for human use.
Brief Description

A selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively.
Description

A selective HDAC5 and HDAC4 inhibitor with IC50 of 4.22 nM and 11.9 nM respectively; less potent for HDAC1/11/2/8; demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 =0.49 and 0.32 uM respectively).
Synonyms

LMK 235;LMK 235
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC4;HDAC5
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1418033-25-6
Formula Weight

294.35
Molecular Formula

C15H22N2O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

O=C(NOCCCCCC(NO)=O)C1=CC(C)=CC(C)=C1
Chemical Name

Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Marek L, et al. J Med Chem. 2013 Jan 24;56(2):427-36.
2. Li A, et al. Eur J Pain. 2013 Sep;17(8):1156-67.

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