Vorinostat
CAS No. 149647-78-9
Vorinostat ( SAHA;Suberoylanilide hydroxamic acid;MK-0683 )
Catalog No. M12074 CAS No. 149647-78-9
A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
200MG | 40 | In Stock |
|
500MG | 77 | In Stock |
|
1G | 91 | In Stock |
|
Biological Information
-
Product NameVorinostat
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
-
DescriptionA potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively; inhibits cell growth, induce terminal differentiation and prevent the formation of tumours in mice models.Blood Cancer Approved
-
SynonymsSAHA;Suberoylanilide hydroxamic acid;MK-0683
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC;HDAC1;HDAC2;HDAC3;HDAC6;HDAC8
-
Research AreaCancer
-
IndicationBlood cancer
Chemical Information
-
CAS Number149647-78-9
-
Formula Weight264.32
-
Molecular FormulaC14H20N2O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 100 mg/mL
-
SMILESO=C(NO)CCCCCCC(NC1=CC=CC=C1)=O
-
Chemical NameOctanediamide, N1-hydroxy-N8-phenyl-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Richon VM, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.
2. Finnin MS, et al. Nature. 1999 Sep 9;401(6749):188-93.
3. Vrana JA, et al. Oncogene. 1999 Nov 25;18(50):7016-25.
4. Richon VM, et al. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10014-9.
2. Finnin MS, et al. Nature. 1999 Sep 9;401(6749):188-93.
3. Vrana JA, et al. Oncogene. 1999 Nov 25;18(50):7016-25.
4. Richon VM, et al. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10014-9.
molnova catalog
related products
-
ACY-775
ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability.
-
MPT0E028
MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells.
-
BRD9757
BRD9757 is a potent, selective HDAC6 inhibitor with IC50 of 8 nM.