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Vorinostat

CAS No. 149647-78-9

Vorinostat ( SAHA;Suberoylanilide hydroxamic acid;MK-0683 )

Catalog No. M12074 CAS No. 149647-78-9

A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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200MG 40 In Stock
500MG 77 In Stock
1G 91 In Stock
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Biological Information

  • Product Name
    Vorinostat
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
  • Description
    A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively; inhibits cell growth, induce terminal differentiation and prevent the formation of tumours in mice models.Blood Cancer Approved
  • Synonyms
    SAHA;Suberoylanilide hydroxamic acid;MK-0683
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC;HDAC1;HDAC2;HDAC3;HDAC6;HDAC8
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    149647-78-9
  • Formula Weight
    264.32
  • Molecular Formula
    C14H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 100 mg/mL
  • SMILES
    O=C(NO)CCCCCCC(NC1=CC=CC=C1)=O
  • Chemical Name
    Octanediamide, N1-hydroxy-N8-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Richon VM, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.
2. Finnin MS, et al. Nature. 1999 Sep 9;401(6749):188-93.
3. Vrana JA, et al. Oncogene. 1999 Nov 25;18(50):7016-25.
4. Richon VM, et al. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10014-9.
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