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Home - Products - Cell Cycle/DNA Damage - DNA Alkylator - Melflufen

Melflufen

CAS No. 380449-51-4

Melflufen ( Melphalan flufenamide;J1 )

Catalog No. M14311 CAS No. 380449-51-4

Melflufen is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo; shows cytotoxic activity against lymphoma cell lines with IC50 of 0.011-0.92 uM, also shows significantly lower IC50 than melphalan in multiple myeloma cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Melflufen
  • Note
    Research use only, not for human use.
  • Brief Description
    Melflufen is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo; shows cytotoxic activity against lymphoma cell lines with IC50 of 0.011-0.92 uM, also shows significantly lower IC50 than melphalan in multiple myeloma cells.
  • Description
    Melflufen (Melphalan flufenamide, J1)is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo; shows cytotoxic activity against lymphoma cell lines with IC50 of 0.011-0.92 uM, also shows significantly lower IC50 than melphalan in multiple myeloma cells; induces apoptosis even in melphalan- and bortezomib-resistant multiple myeloma cells.Blood Cancer Phase 3 Clinical
  • Synonyms
    Melphalan flufenamide;J1
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA Alkylator
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    380449-51-4
  • Formula Weight
    498.42
  • Molecular Formula
    C24H30Cl2FN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCOC(=O)C(CC1=CC=C(C=C1)F)NC(=O)C(CC2=CC=C(C=C2)N(CCCl)CCCl)N
  • Chemical Name
    ethyl (S)-2-((S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wickstrm M, et al. Oncotarget. 2017 Jun 8;8(39):66641-66655.
2. Carlier C, et al. Oncotarget. 2016 Sep 13;7(37):59322-59335.
3. Delforoush M, et al. BMC Cancer. 2016 Apr 4;16:263.
4. Chauhan D, et al. Clin Cancer Res. 2013 Jun 1;19(11):3019-31.
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