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Home - Products - Cell Cycle/DNA Damage - DNA Alkylator - KCC-07

KCC-07

CAS No. 315702-75-1

KCC-07 ( —— )

Catalog No. M22191 CAS No. 315702-75-1

KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 Get Quote
5MG 65 Get Quote
10MG 113 Get Quote
25MG 222 Get Quote
50MG 354 Get Quote
100MG 527 Get Quote
500MG 1143 Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    KCC-07
  • Note
    Research use only, not for human use.
  • Brief Description
    KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity.
  • Description
    KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. In vitro, KCC-07 treatment Medulloblastomas (MB) cells?clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    MBD2 (methyl-CpG-binding domain protein 2)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315702-75-1
  • Formula Weight
    269.32
  • Molecular Formula
    C14H11N3OS?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Oc1cccc(Nc2nc(cs2)-c2ccccn2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5.
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