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KCC-07
CAS No. 315702-75-1
KCC-07( —— )
Catalog No. M22191 CAS No. 315702-75-1
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | Get Quote |
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| 5MG | 65 | Get Quote |
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| 10MG | 113 | Get Quote |
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| 25MG | 222 | Get Quote |
|
| 50MG | 354 | Get Quote |
|
| 100MG | 527 | Get Quote |
|
| 500MG | 1143 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameKCC-07
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NoteResearch use only, not for human use.
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Brief DescriptionKCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity.
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DescriptionKCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. In vitro, KCC-07 treatment Medulloblastomas (MB) cells clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling.
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In VitroCell Viability Assay Cell Line:Medulloblastomas (MB) cells Concentration:10 μM Incubation Time:72 hours Result:Clearly inhibited MB cell growth in vitro.Western Blot Analysis Cell Line:Medulloblastomas (MB) cells Concentration:10 μM Incubation Time:48 hours Result:Largely abrogated MBD2 binding to the ADGRB1 promoter in BAI1-silent MB cells.
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In VivoAnimal Model:Outbred athymic nude mice (females; 8-10 weeks old) injected with MB cells Dosage:100 mg/kg Administration:Intraperitoneal injection; 5 days/week Result:Significantly extended the survival of MB xenografts in vivo.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA Alkylator
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RecptorMBD2 (methyl-CpG-binding domain protein 2)
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Research Area——
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Indication——
Chemical Information
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CAS Number315702-75-1
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Formula Weight269.32
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Molecular FormulaC14H11N3OS?
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (464.13 mM)
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SMILESOc1cccc(Nc2nc(cs2)-c2ccccn2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5.
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