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Mavatrep

CAS No. 956274-94-5

Mavatrep ( JNJ-39439335 )

Catalog No. M16825 CAS No. 956274-94-5

A selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mavatrep
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).
  • Description
    A selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx); exhibits potent in vitro functional activity and robust oral efficacy in multiple models of inflammatory pain.Pain Phase 1 Clinical
  • Synonyms
    JNJ-39439335
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    956274-94-5
  • Formula Weight
    422.44
  • Molecular Formula
    C25H21F3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2
  • Chemical Name
    Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Parsons WH, et al. J Med Chem. 2015 May 14;58(9):3859-74.
2. Mayorga AJ, et al. Scand J Pain. 2017 Aug 24;17:134-143.
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