Mavatrep ( JNJ-39439335 )

Catalog No. M16825 CAS No. 956274-94-5

COA

Datasheet

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HPLC

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Product Name

Mavatrep
Note

Research use only, not for human use.
Brief Description

A selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).
Description

A selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx); exhibits potent in vitro functional activity and robust oral efficacy in multiple models of inflammatory pain.Pain Phase 1 Clinical
Synonyms

JNJ-39439335
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRP/TRPV Channel
Research Area

Neurological Disease
Indication

Pain

CAS Number

956274-94-5
Formula Weight

422.44
Molecular Formula

C25H21F3N2O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 28 mg/mL
SMILES

OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2
Chemical Name

Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-

1. Parsons WH, et al. J Med Chem. 2015 May 14;58(9):3859-74.
2. Mayorga AJ, et al. Scand J Pain. 2017 Aug 24;17:134-143.

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