Cart
sales@molnova.com
MW181
CAS No. 1454658-87-7
MW181( MW01-10-181SRM )
Catalog No. M11961 CAS No. 1454658-87-7
MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMW181
-
NoteResearch use only, not for human use.
-
Brief DescriptionMW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM.
-
DescriptionMW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ; suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production, suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice, significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.
-
In Vitro——
-
In Vivo——
-
SynonymsMW01-10-181SRM
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
Recptorp38 MAPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1454658-87-7
-
Formula Weight326.403
-
Molecular FormulaC21H18N4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameN,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.
2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.
3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.
molnova catalog
related products
-
SKLB-163
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
-
AL 8697
AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.
-
LY2228820 dimesylate
LY2228820 dimesylate (Ralimetinib) is a potent, selective, orally available inhibitor p38 MAPK with IC50 of 5.3 and 3.2 nM for p38α and p38β, respectively.
