MSN-125 ( MSN 125;MSN125 )

Catalog No. M12275 CAS No. 1592908-16-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MSN-125
Note

Research use only, not for human use.
Brief Description

MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.
Description

MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
Synonyms

MSN 125;MSN125
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

1592908-16-1
Formula Weight

688.62
Molecular Formula

C36H38BrN3O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@H](C(N([C@@H]1[C@@H](CN)OC2=CC(OCOCCOC)=CC=C12)CC3=CC=C(Br)C=C3)=O)CC4=CC=CC=C4)C5=CC=CC=C5
Chemical Name

N-{1(S)-[[2(R)-Aminomethyl-6-(2-methoxy-ethoxymethoxy)-2,3-dihydro-benzofuran-3(S)-yl]-(4-bromo-benzyl)-carbamoyl]-2-phenyl-ethyl}-benzamide

1. Niu X, et al.Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.

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