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MSN-125

CAS No. 1592908-16-1

MSN-125( MSN 125 | MSN125 )

Catalog No. M12275 CAS No. 1592908-16-1

MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MSN-125
  • Note
    Research use only, not for human use.
  • Brief Description
    MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.
  • Description
    MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MSN 125 | MSN125
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1592908-16-1
  • Formula Weight
    688.619
  • Molecular Formula
    C36H38BrN3O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (290.44 mM)
  • SMILES
    O=C(N[C@H](C(N([C@@H]1[C@@H](CN)OC2=CC(OCOCCOC)=CC=C12)CC3=CC=C(Br)C=C3)=O)CC4=CC=CC=C4)C5=CC=CC=C5
  • Chemical Name
    N-{1(S)-[[2(R)-Aminomethyl-6-(2-methoxy-ethoxymethoxy)-2,3-dihydro-benzofuran-3(S)-yl]-(4-bromo-benzyl)-carbamoyl]-2-phenyl-ethyl}-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Niu X, et al.?Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.
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