S44563

Research use only, not for human use.

S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.

S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively; induces in vitro apoptosis of melanoma xenograft-derived cell lines MP41, MM26, and MM66 with IC50 of 4, 7 and 6 uM; increases the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine in vivo, also enhance radiosensitivity of SCLC cells in vitro and in vivo.

S 44563

Angiogenesis

Bcl-2

Bcl-2

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1044900-59-5

839.47

C44H47ClN6O5S2

>98% (HPLC)

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(4aR)-3-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxamide

(-20℃)

With Ice Pack

≥ 2 years