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MSDC-0160

CAS No. 146062-49-9

MSDC-0160 ( PNU-91325;Mitoglitazone )

Catalog No. M11984 CAS No. 146062-49-9

A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 63 In Stock
10MG 91 In Stock
25MG 140 In Stock
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Biological Information

  • Product Name
    MSDC-0160
  • Note
    Research use only, not for human use.
  • Brief Description
    A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).
  • Description
    A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM) and shows insulin-sensitizing effects in mouse models of diabetes; increases AMPK activity and reduces mTOR activity, maintains β-cell phenotype in human islets.Diabetes Phase 2 Clinical
  • Synonyms
    PNU-91325;Mitoglitazone
  • Pathway
    Tyrosine Kinase
  • Target
    Insulin Receptor
  • Recptor
    mTOT
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    146062-49-9
  • Formula Weight
    370.42
  • Molecular Formula
    C19H18N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    O=C(N1)SC(CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O
  • Chemical Name
    2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Colca JR, et al. Clin Pharmacol Ther. 2013 Apr;93(4):352-9.
2. Bolten CW, et al. Gene Regul Syst Bio. 2007 Sep 17;1:73-82.
3. Rohatgi N, et al. PLoS One. 2013 May 1;8(5):e62012.
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