MSDC-0160
CAS No. 146062-49-9
MSDC-0160 ( PNU-91325;Mitoglitazone )
Catalog No. M11984 CAS No. 146062-49-9
A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).
Purity : >98% (HPLC)
Size | Price / USD | Stock | Quantity |
2MG | 39 | In Stock |
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5MG | 63 | In Stock |
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10MG | 91 | In Stock |
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25MG | 140 | In Stock |
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50MG | 186 | In Stock |
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100MG | 332 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameMSDC-0160
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NoteResearch use only, not for human use.
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Brief DescriptionA new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).
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DescriptionA new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM) and shows insulin-sensitizing effects in mouse models of diabetes; increases AMPK activity and reduces mTOR activity, maintains β-cell phenotype in human islets.Diabetes Phase 2 Clinical
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SynonymsPNU-91325;Mitoglitazone
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PathwayTyrosine Kinase
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TargetInsulin Receptor
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RecptormTOT
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number146062-49-9
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Formula Weight370.42
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Molecular FormulaC19H18N2O4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO=C(N1)SC(CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O
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Chemical Name2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
2. Bolten CW, et al. Gene Regul Syst Bio. 2007 Sep 17;1:73-82.
3. Rohatgi N, et al. PLoS One. 2013 May 1;8(5):e62012.
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