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Insulin Receptor
Insulin is an anabolic peptide hormone secreted by the b-cells of the pancreas that plays a critical role in the regulation of human metabolism.Insulin is widely viewed as a glucose homeostasis regulating hormone, it is now known to have a much broader pleiotropic role. An insulin-like signaling system exists in all metazoans, and regulates evolutionarily conserved processes including reproduction and lifespan.The receptor activates a complex intracellular signaling network through IRS proteins and the canonical PI3K and ERK cascades.Insulin signaling in the liver and b cell is emerging as the major determinant in preventing type 2 diabetes, through the integrative role of molecules like IRS2 and FOXO, preventing b cell dedifferentiation.
References
1.Pierre De Meyts, MD, PhD, F.A.C.E.Endotext [Internet]. 2.Lee J, Pilch PF. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34.
References
1.Pierre De Meyts, MD, PhD, F.A.C.E.Endotext [Internet]. 2.Lee J, Pilch PF. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34.
Tyrosine Kinase
Insulin Receptor
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[D-Ala2]-GIP (human)
catalog no : M30673
cas no: 444073-04-5
Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD.
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GIP (human)
catalog no : M30672
cas no: 100040-31-1
Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic β-cells.
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GIP (1-30) amide (Human)
catalog no : M30283
cas no: 198624-01-0
GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (GIP) is an insulin secreting hormone, which can stimulate the secretion of insulin and reduce the occurrence of postpranal-glycemic diseases.
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Insulin Receptor 1142-1153
catalog no : M29958
cas no: 141171-54-2
[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) binds to insulin and can be used as insulin receptor tyrosine kinase substrates.
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Insulin degludec
catalog no : M25046
cas no: 844439-96-9
Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM/L for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.