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MS-453
CAS No. 2059892-29-2
MS-453( MS453 | MS 453 )
Catalog No. M13201 CAS No. 2059892-29-2
A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMS-453
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.
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DescriptionA potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM; exhibits selectivity for SETD8 against 28 other methyltransferases; does not causes significant reduction in the H4K20me in HeLa cells at up to 10 uM; poor membrane permeability (4.4 nm/s) and high efflux ratio (137).
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In Vitro——
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In Vivo——
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SynonymsMS453 | MS 453
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number2059892-29-2
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Formula Weight385.468
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Molecular FormulaC20H27N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=C(OC)C=C(N=C(N2CCCC2)N=C3NCCCNC(C=C)=O)C3=C1
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Chemical NameN-(3-((6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Butler KV, et al. J Med Chem. 2016 Nov 10;59(21):9881-9889.
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