MS-453 ( MS453;MS 453 )

Catalog No. M13201 CAS No. 2059892-29-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MS-453
Note

Research use only, not for human use.
Brief Description

A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.
Description

A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM; exhibits selectivity for SETD8 against 28 other methyltransferases; does not causes significant reduction in the H4K20me in HeLa cells at up to 10 uM; poor membrane permeability (4.4 nm/s) and high efflux ratio (137).
Synonyms

MS453;MS 453
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Other Indications
Indication

——

CAS Number

2059892-29-2
Formula Weight

385.47
Molecular Formula

C20H27N5O3
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=C(OC)C=C(N=C(N2CCCC2)N=C3NCCCNC(C=C)=O)C3=C1
Chemical Name

N-(3-((6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide

1. Butler KV, et al. J Med Chem. 2016 Nov 10;59(21):9881-9889.

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