MS-402

Research use only, not for human use.

MS-402 (MS402) is a potent, selective inhibitor of the first bromodomain of BET (BRD4-BD1) with Ki of 77 nM.

MS-402 (MS402) is a potent, selective inhibitor of the first bromodomain of BET (BRD4-BD1) with Ki of 77 nM; shows about 10-fold weaker affinity for BRD4-BD2 (Ki=718 nM) and CBP, and >50-fold for PCAF, SMARCA4, BPTF and BAZ2B; selectively blocks Th17 cell differentiation with a little or almost no effect on Th1 or Th2 and Treg cells; preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation; prevents and ameliorates T-cell transfer-induced colitis in mice.

MS402;MS 402

Chromatin/Epigenetic

Bromodomain

Bromodomain

——

——

1672684-68-2

370.83

C20H19ClN2O3

>98% (HPLC)

——

O=C(NC1=CC=C(OC)C=C1)C2=CC=C(NC3=C(C)C(CC3)=O)C(Cl)=C2

3-chloro-N-(4-methoxyphenyl)-4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)benzamide

(-20℃)

With Ice Pack

≥ 2 years