GS-626510 ( GS-6510;GS 6510;GS 626510 )

Catalog No. M12471 CAS No. 1637770-13-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GS-626510
Note

Research use only, not for human use.
Brief Description

GS-626510 (GS-6510, GS 6510, GS 626510) is anovel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT.
Description

GS-626510 (GS-6510, GS 6510, GS 626510) is anovel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT; shows weak affinity for CREBBP and EP300 (Ki=170 and 220 nM); potently inhibits growth of RKO cells with IC50 of 33 nM, decreases MYC levels; TRIM33 is required for the ability of GS-626510 to maximally down-regulate MYC.
Synonyms

GS-6510;GS 6510;GS 626510
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1637770-13-8
Formula Weight

394.48
Molecular Formula

C25H22N4O
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(C2=CC(C3=C4C=CC=NC4=CC=C3C)=C5NC(C6CC6)=NC5=C2)C(C)=NO1
Chemical Name

4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole

1. Shi X, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.

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