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MS-377
CAS No. 206862-30-8
MS-377( MS377 )
Catalog No. M13214 CAS No. 206862-30-8
MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMS-377
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NoteResearch use only, not for human use.
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Brief DescriptionMS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM.
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DescriptionMS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities; markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain.Schizophrenia Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMS377
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PathwayAutophagy
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TargetSigma receptor
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RecptorSigma Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number206862-30-8
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Formula Weight351.875
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Molecular FormulaC18H26ClN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-1-(4-chlorophenyl)-3-((4-(2-methoxyethyl)piperazin-1-yl)methyl)pyrrolidin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takahashi S, et al. Psychopharmacology (Berl). 1999 Aug;145(3):295-302.
2. Karasawa J, et al. Eur J Pharmacol. 2000 Jul 14;400(1):51-7.
3. Yamada S, et al. Eur J Pharmacol. 2000 Aug 25;402(3):251-4.
4. Takahashi S, et al. Eur J Pharmacol. 2001 Sep 21;427(3):211-9.
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