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MRTX9768
CAS No. 2629314-68-5
MRTX9768 ( MRTX-9768; MRTX9768 )
Catalog No. M28771 CAS No. 2629314-68-5
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 642 | Get Quote |
|
| 10MG | 1017 | Get Quote |
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| 25MG | 1521 | Get Quote |
|
| 50MG | 2043 | Get Quote |
|
| 100MG | 2673 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMRTX9768
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NoteResearch use only, not for human use.
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Brief DescriptionMRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
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DescriptionMRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.(In Vitro):MRTX-9768, a potent inhibitor of SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM).(In Vivo):In xenograft studies, oral administration of MRTX-9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow.
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SynonymsMRTX-9768; MRTX9768
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorCK2
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Research Area——
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Indication——
Chemical Information
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CAS Number2629314-68-5
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Formula Weight424.4
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Molecular FormulaC24H17FN6O
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Purity>98% (HPLC)
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Solubility——
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SMILESFC1=C(C2=C(C3=CC=C(C(NN=C4CN)=O)C4=C3)C=NN2C)C(C#N)=C(C=CC=C5)C5=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Golub A G , Bdzhola V G , Briukhovetska N V , et al. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2[J]. European Journal of Medicinal Chemistry, 2011, 46(3):870-876.
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