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Home - Products - Chromatin/Epigenetic - Histone Demethylase - MRTX9768

MRTX9768

CAS No. 2629314-68-5

MRTX9768( MRTX-9768 | MRTX9768 )

Catalog No. M28771 CAS No. 2629314-68-5

MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MRTX9768
  • Note
    Research use only, not for human use.
  • Brief Description
    MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
  • Description
    MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.(In Vitro):MRTX-9768, a potent inhibitor of SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM).(In Vivo):In xenograft studies, oral administration of MRTX-9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MRTX-9768 | MRTX9768
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    CK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2629314-68-5
  • Formula Weight
    424.43
  • Molecular Formula
    C24H17FN6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (117.81 mM)
  • SMILES
    FC1=C(C2=C(C3=CC=C(C(NN=C4CN)=O)C4=C3)C=NN2C)C(C#N)=C(C=CC=C5)C5=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Golub A G , Bdzhola V G , Briukhovetska N V , et al. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2[J]. European Journal of Medicinal Chemistry, 2011, 46(3):870-876.
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