CPI-455 ( CPI455;CPI 455 )

Catalog No. M12423 CAS No. 1628208-23-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CPI-455
Note

Research use only, not for human use.
Brief Description

A potent, specific histone demethylase pan-KDM5 inhibitor with biochemical IC50 of 10, 3 and 14 nM for KDM5A, KDM5B and KDM5C, respectively.
Description

A potent, specific histone demethylase pan-KDM5 inhibitor with biochemical IC50 of 10, 3 and 14 nM for KDM5A, KDM5B and KDM5C, respectively; shows substantially weaker potency toward KDM4C and KDM7B (200- and 770-fold, respectively) and no inhibition of KDM2B, KDM3B or KDM6A; dose-dependently increases in H3K4 methylation in multiple cell lines, decreases the number of drug-tolerant persister cancer cells (DTPs) in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
Synonyms

CPI455;CPI 455
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

KDM5A
Research Area

Cancer
Indication

——

CAS Number

1628208-23-0
Formula Weight

278.31
Molecular Formula

C16H14N4O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 34 mg/mL
SMILES

N#CC1=C(NC(C2=CC=CC=C2)=C(C(C)C)C3=O)N3N=C1
Chemical Name

Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-

1. Vinogradova M, et al. Nat Chem Biol. 2016 Jul;12(7):531-8.
2. Banelli B, et al. Oncotarget. 2017 May 23;8(21):34896-34910.

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