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MRT67307
CAS No. 1190378-57-4
MRT67307( MRT 67307 | MRT-67307 )
Catalog No. M10651 CAS No. 1190378-57-4
MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 114 | In Stock |
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| 25MG | 227 | In Stock |
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| 50MG | 437 | In Stock |
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| 100MG | 623 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMRT67307
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NoteResearch use only, not for human use.
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Brief DescriptionMRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.
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DescriptionMRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells; the autophagy-inhibiting capacity of MRT67307 is specifically through ULK1, results in accumulation of stalled early autophagosomal structures in treated cells; increases IL-10 production and suppresses proinflammatory cytokine production in macrophages, increases CREB-dependent gene transcription by promoting the dephosphorylation of CRTC3; also inhibits MARK, NUAK and SIK isoforms in vitro with comparable potency to the IKK-related kinases.
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In Vitro——
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In Vivo——
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SynonymsMRT 67307 | MRT-67307
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PathwayAutophagy
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TargetULK
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RecptorIKK?|TBK1
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1190378-57-4
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Formula Weight464.603
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Molecular FormulaC26H36N6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5
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Chemical NameCyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Clark K, et al. Biochem J. 2011 Feb 15;434(1):93-104.
2. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
3. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.
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MRT67307
MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.
