MRT-68921 ( MRT68921;MRT 68921 )

Catalog No. M10652 CAS No. 1190379-70-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MRT-68921
Note

Research use only, not for human use.
Brief Description

A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
Description

A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.
Synonyms

MRT68921;MRT 68921
Pathway

Autophagy
Target

ULK
Recptor

ULK1;ULK2
Research Area

——
Indication

——

CAS Number

1190379-70-4
Formula Weight

434.58
Molecular Formula

C25H34N6O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5
Chemical Name

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

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