FT895( FT 895 | FT-895 )

Catalog No. M13554 CAS No. 2225728-57-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FT895
Note

Research use only, not for human use.
Brief Description

FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM.
Description

FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM, displays no significant activity against HDAC1-10 (IC50>5 uM); displays promising cellular activity (IC50<20 nM) and pharmacokinetic properties; FT895 is a useful tool to study the biology of HDAC11 and shows potential use as a therapeutic target for oncology and inflammation indications.
In Vitro

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In Vivo

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Synonyms

FT 895 | FT-895
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

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Indication

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CAS Number

2225728-57-2
Formula Weight

352.317
Molecular Formula

C16H15F3N4O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (354.80 mM)
SMILES

O=C(NO)C1=C(CN(C2=CN=C(C(F)(F)F)C=N2)C3(C)C)C3=CC=C1
Chemical Name

N-hydroxy-1,1-dimethyl-2-(5-(trifluoromethyl)pyrazin-2-yl)isoindoline-4-carboxamide

1. Martin MW, et al. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2143-2147.

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