CM-675( CM675 | CM 675 )

Catalog No. M12901 CAS No. 1872466-47-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CM-675
Note

Research use only, not for human use.
Brief Description

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
Description

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively; displays >10-fold selectivity over HDAC6; induces significant cellular responses (AcH3K9 and pCREB) at low concentrations (26-100 nM) with little cytotoxicity; shows an adequate ADME-Tox profile and in vivo target engagement (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation) in the central nervous system (CNS).
In Vitro

CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) .
In Vivo

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Synonyms

CM675 | CM 675
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

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Indication

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CAS Number

1872466-47-1
Formula Weight

536.636
Molecular Formula

C31H32N6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (46.59 mM)
SMILES

CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C
Chemical Name

N-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]benzamide

1. Rabal O, et al. ACS Chem Neurosci. 2018 Dec 10. doi: 10.1021/acschemneuro.8b00648.

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