CM-675 ( CM675;CM 675 )

Catalog No. M12901 CAS No. 1872466-47-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

CM-675
Note

Research use only, not for human use.
Brief Description

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
Description

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively; displays >10-fold selectivity over HDAC6; induces significant cellular responses (AcH3K9 and pCREB) at low concentrations (26-100 nM) with little cytotoxicity; shows an adequate ADME-Tox profile and in vivo target engagement (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation) in the central nervous system (CNS).
Synonyms

CM675;CM 675
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1872466-47-1
Formula Weight

536.64
Molecular Formula

C31H32N6O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C
Chemical Name

N-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]benzamide

1. Rabal O, et al. ACS Chem Neurosci. 2018 Dec 10. doi: 10.1021/acschemneuro.8b00648.

Calculator

molnova catalog