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MPK-09
CAS No. 1431884-83-1
MPK-09( MPK09 | MPK 09 )
Catalog No. M11836 CAS No. 1431884-83-1
A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMPK-09
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.
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DescriptionA highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator; exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells; enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis.
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In Vitro——
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In Vivo——
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SynonymsMPK09 | MPK 09
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1431884-83-1
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Formula Weight418.53
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Molecular FormulaC24H34O6
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCCOC(C1C(OC(O1)(C)C)C(=O)C=CC(=O)OCC)C2=CC=CC=C2
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Chemical Name(2E)-4-[(4R,5S)-5-[(R)-(Hexyloxy)phenylmethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxo-2-butenoic acid ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Metri PK, et al. ACS Chem Biol. 2013 Jul 19;8(7):1429-34.
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