MPK-09

CAS No. 1431884-83-1

MPK-09( MPK09 | MPK 09 )

Catalog No. M11836 CAS No. 1431884-83-1

A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MPK-09
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.
  • Description
    A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator; exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells; enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MPK09 | MPK 09
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1431884-83-1
  • Formula Weight
    418.53
  • Molecular Formula
    C24H34O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCCCOC(C1C(OC(O1)(C)C)C(=O)C=CC(=O)OCC)C2=CC=CC=C2
  • Chemical Name
    (2E)-4-[(4R,5S)-5-[(R)-(Hexyloxy)phenylmethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxo-2-butenoic acid ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Metri PK, et al. ACS Chem Biol. 2013 Jul 19;8(7):1429-34.
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