MPC-0767

Research use only, not for human use.

MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100.

MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM; exhibits improved aqueous solubility, adequate chemical stability, and rapid bioconversion without the need for solubilizing excipients.

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MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the Tmax, Cmax, AUC and F% are 1?(h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively.MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals.MPC-0767 is well tolerated when administered at 252?mg/kg po (equivalent to 200?mg/kg dose of?MPC-3100).

MPC 0767 | MPC0767 | MPC3100 mesylate hydrate

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

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1310540-32-9

663.559

C23H31BrN6O8S2

>98% (HPLC)

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O.C[C@H](N)C(=O)O[C@@H](C)C(=O)N1CCC(CCn2c(Sc3cc4OCOc4cc3Br)nc5c(N)ncnc25)CC1.CS(=O)(=O)O

(2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-1-propanone mesylate hydrate

(-20℃)

With Ice Pack

≥ 2 years