MOMIPP
CAS No. 1363421-46-8
MOMIPP ( —— )
Catalog No. M27997 CAS No. 1363421-46-8
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 224 | Get Quote |
|
10MG | 357 | Get Quote |
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25MG | 596 | Get Quote |
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50MG | 848 | Get Quote |
|
100MG | 1152 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameMOMIPP
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NoteResearch use only, not for human use.
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Brief DescriptionMOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.
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DescriptionMOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.(In Vitro):MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations. MOMIPP(3 μM) induces cell vacuolization in U373 and Hs683 cell lines. The cytotoxic IPP compound, MOMIPP, causes early disruptions of glucose uptake and glycolytic metabolism. Coincident with these metabolic changes, MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL.(In Vivo):MOMIPP (80?mg/kg; i.p.; once daily; for 15 consecutive days) shows result that MOMIPP is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorSOS1
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Research Area——
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Indication——
Chemical Information
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CAS Number1363421-46-8
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Formula Weight292.3
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Molecular FormulaC18H16N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1ccc2[nH]c(C)c(\C=C\C(=O)c3ccncc3)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Matthew Arnold Marx, et al. Sos1 inhibitors. WO2021127429 A1.
molnova catalog
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