GDC-0326 ( GDC 0326;GDC0326 )

Catalog No. M11160 CAS No. 1282514-88-8

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Datasheet

HNMR

HPLC

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Product Name

GDC-0326
Note

Research use only, not for human use.
Brief Description

A potent, selective, orally available PI3Kα inhibitor with Ki of 0.2 nM; displays 133, 20 and 33-fold selectivity over PI3Kβ, PI3Kδ and PI3Kγ, respectively.
Description

A potent, selective, orally available PI3Kα inhibitor with Ki of 0.2 nM; displays 133, 20 and 33-fold selectivity over PI3Kβ, PI3Kδ and PI3Kγ, respectively; inhibits MCF7-neo/HER2 and PC3 cells proliferation with IC50 of 0.1 uM and 2.2 uM, respectively; reduces tumor growth as well as vascular area in vivo, also reduces the incidence of liver and lymph node metastasis.
Synonyms

GDC 0326;GDC0326
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kα
Research Area

Cancer
Indication

——

CAS Number

1282514-88-8
Formula Weight

382.42
Molecular Formula

C19H22N6O3
Purity

>98% (HPLC)
Solubility

DMSO: 69 mg/mL (180.5 mM); Water: Insoluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O
Chemical Name

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide

1. Heffron TP, et al. J Med Chem. 2016 Feb 11;59(3):985-1002.
2. Soler A, et al. Clin Cancer Res. 2016 Dec 1;22(23):5805-5817.

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