MM3122
CAS No. 2574390-27-3
MM3122 ( Ac-GQFR-kbt; GTPL11533; MM-3122 )
Catalog No. M28534 CAS No. 2574390-27-3
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 107 | Get Quote |
|
5MG | 178 | Get Quote |
|
10MG | 287 | Get Quote |
|
25MG | 537 | Get Quote |
|
50MG | 779 | Get Quote |
|
100MG | 1044 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMM3122
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NoteResearch use only, not for human use.
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Brief DescriptionMM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
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DescriptionMM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.(In Vitro):MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively. MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3 and VSV-SARS CoV-2 chimera calu-3 with the EC50 values of 74, 0.87 nM and 0.43 respectively .(In Vivo):MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls. MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice.
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SynonymsAc-GQFR-kbt; GTPL11533; MM-3122
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2574390-27-3
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Formula Weight665.8
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Molecular FormulaC31H39N9O6S
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Purity>98% (HPLC)
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Solubility——
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SMILESC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC(C)=O)=O)CCC(N)=O)=O)=O)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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