MM3122

CAS No. 2574390-27-3

MM3122 ( Ac-GQFR-kbt; GTPL11533; MM-3122 )

Catalog No. M28534 CAS No. 2574390-27-3

MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 107 Get Quote
5MG 178 Get Quote
10MG 287 Get Quote
25MG 537 Get Quote
50MG 779 Get Quote
100MG 1044 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    MM3122
  • Note
    Research use only, not for human use.
  • Brief Description
    MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
  • Description
    MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.(In Vitro):MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively. MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3 and VSV-SARS CoV-2 chimera calu-3 with the EC50 values of 74, 0.87 nM and 0.43 respectively .(In Vivo):MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls. MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice.
  • Synonyms
    Ac-GQFR-kbt; GTPL11533; MM-3122
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2574390-27-3
  • Formula Weight
    665.8
  • Molecular Formula
    C31H39N9O6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC(C)=O)=O)CCC(N)=O)=O)=O)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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