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Home - Products - Chromatin/Epigenetic - HMTase - MM-589

MM-589

CAS No. 2097887-21-1

MM-589( MM 589 | MM589 )

Catalog No. M13312 CAS No. 2097887-21-1

A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MM-589
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
  • Description
    A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM; inhibits the MLL H3K4 methyltransferase activity (IC50=12.7 nM), potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations, and shows >40-fold better than MM-401.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MM 589 | MM589
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2097887-21-1
  • Formula Weight
    686.734
  • Molecular Formula
    C30H45F3N8O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCC1C(=O)NC(C(=O)NCCC(C(=O)NC(C(=O)N1)CCCNC(=NC)N)(C)NC(=O)C(C)C)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
  • Chemical Name
    N-((3R,6S,9S,12R)-6-ethyl-12-methyl-9-(3-(3-methylguanidino)propyl)-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl)isobutyramide 2,2,2-trifluoroacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Karatas H, et al. J Med Chem. 2017 Jun 22;60(12):4818-4839.
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