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ML339

CAS No. 2579689-83-9

ML339( —— )

Catalog No. M28860 CAS No. 2579689-83-9

ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML339
  • Note
    Research use only, not for human use.
  • Brief Description
    ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
  • Description
    ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.(In Vitro):The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CXCR
  • Recptor
    CDK9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2579689-83-9
  • Formula Weight
    502
  • Molecular Formula
    C26H32ClN3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 75 mg/mL (149.40 mM)
  • SMILES
    O=C(NC1=CC=CC=C1Cl)CN2[C@H]3C[C@@H](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)C[C@@H]2CCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
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