Cart
sales@molnova.com
ML339
CAS No. 2579689-83-9
ML339( —— )
Catalog No. M28860 CAS No. 2579689-83-9
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | Get Quote |
|
| 10MG | 132 | Get Quote |
|
| 25MG | 267 | Get Quote |
|
| 50MG | 430 | Get Quote |
|
| 100MG | 620 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameML339
-
NoteResearch use only, not for human use.
-
Brief DescriptionML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
-
DescriptionML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.(In Vitro):The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayAutophagy
-
TargetCXCR
-
RecptorCDK9
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2579689-83-9
-
Formula Weight502
-
Molecular FormulaC26H32ClN3O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 75 mg/mL (149.40 mM)
-
SMILESO=C(NC1=CC=CC=C1Cl)CN2[C@H]3C[C@@H](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)C[C@@H]2CCC3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
molnova catalog
related products
-
TC14012
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity.
-
CHIR98014
CHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
-
Reparixin L-lysine s...
Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
