ML339

CAS No. 2579689-83-9

ML339( —— )

Catalog No. M28860 CAS No. 2579689-83-9

ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 80 Get Quote
10MG 132 Get Quote
25MG 267 Get Quote
50MG 430 Get Quote
100MG 620 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ML339
  • Note
    Research use only, not for human use.
  • Brief Description
    ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
  • Description
    ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.(In Vitro):The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CXCR
  • Recptor
    CDK9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2579689-83-9
  • Formula Weight
    502
  • Molecular Formula
    C26H32ClN3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 75 mg/mL (149.40 mM)
  • SMILES
    O=C(NC1=CC=CC=C1Cl)CN2[C@H]3C[C@@H](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)C[C@@H]2CCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
molnova catalog
related products
  • TC14012

    TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity.

  • CHIR98014

    CHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.

  • Reparixin L-lysine s...

    Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.