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ML339
CAS No. 2579689-83-9
ML339( —— )
Catalog No. M28860 CAS No. 2579689-83-9
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | Get Quote |
|
| 10MG | 132 | Get Quote |
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| 25MG | 267 | Get Quote |
|
| 50MG | 430 | Get Quote |
|
| 100MG | 620 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameML339
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NoteResearch use only, not for human use.
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Brief DescriptionML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
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DescriptionML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.(In Vitro):The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetCXCR
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RecptorCDK9
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Research Area——
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Indication——
Chemical Information
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CAS Number2579689-83-9
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Formula Weight502
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Molecular FormulaC26H32ClN3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 75 mg/mL (149.40 mM)
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SMILESO=C(NC1=CC=CC=C1Cl)CN2[C@H]3C[C@@H](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)C[C@@H]2CCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
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