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CHIR98014

CAS No. 556813-39-9

CHIR98014( CHIR98014 | CHIR-98014 | CHIR 98014 )

Catalog No. M17541 CAS No. 556813-39-9

CHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CHIR98014
  • Note
    Research use only, not for human use.
  • Brief Description
    CHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
  • Description
    CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CHIR98014 | CHIR-98014 | CHIR 98014
  • Pathway
    Autophagy
  • Target
    CXCR
  • Recptor
    GSK-3α/β| p70 S6K
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    556813-39-9
  • Formula Weight
    486.31
  • Molecular Formula
    C20H17Cl2N9O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (257.04 mM)
  • SMILES
    c1cc(c(cc1Cl)Cl)c1nc(ncc1c1[nH]ccn1)NCCNc1nc(c(cc1)[N+](=O)[O-])N
  • Chemical Name
    N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ring DB,et al. Diabetes. 2003, 52(3), 588-595.
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