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ML-SA5

CAS No. 2418670-70-7

ML-SA5( —— )

Catalog No. M28506 CAS No. 2418670-70-7

ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ML-SA5
  • Note
    Research use only, not for human use.
  • Brief Description
    ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.
  • Description
    ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.(In Vitro):Activating MCOLN1 with ML-SA5 triggers cell death of a number of cancer cells by evoking autophagic arrest and subsequent apoptotic response and cell cycle arrest, with little or no effect observed on normal cells.(In Vivo):ML-SA5 in Patu 8988 t xenograft mice profoundly suppresses tumor growth and improves survival.
  • In Vitro
    ML-SA5(1-100 μM, 24 h) has some cell-targeting specificity and induces substantial cell death in M12 and MeWo cells, but fully preserves normal melanocytes. It also causes a loss of mitochondrial membrane potential in M12 cells.
  • In Vivo
    ML-SA5 (i.p., 2-5 mg/kg, daily, 2 weeks) reduces muscle necrosis in MDX mice by more than 70% and reduces central nucleated fibers, suggesting that ML-SA5 can improve muscle atrophy in mdx mice in vivo by promoting myosin repair, but has no effect in ML1 knockout mice. Moreover, ML-SA5 reduces skeletal and cardiac muscle damage in mdx mice through ML1 upregulation.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2418670-70-7
  • Formula Weight
    457.99
  • Molecular Formula
    C19H24ClN3O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (272.93 mM)
  • SMILES
    O=S(=O)(NC=1C=CC=C(Cl)C1N2CCCCC2)C3=CC=C(C=C3)S(=O)(=O)N(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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