ML-SA5

Research use only, not for human use.

ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.

ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.(In Vitro):Activating MCOLN1 with ML-SA5 triggers cell death of a number of cancer cells by evoking autophagic arrest and subsequent apoptotic response and cell cycle arrest, with little or no effect observed on normal cells.(In Vivo):ML-SA5 in Patu 8988 t xenograft mice profoundly suppresses tumor growth and improves survival.

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Autophagy

Autophagy

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2418670-70-7

458.0

C19H24ClN3O4S2

>98% (HPLC)

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O=S(=O)(NC=1C=CC=C(Cl)C1N2CCCCC2)C3=CC=C(C=C3)S(=O)(=O)N(C)C

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(-20℃)

With Ice Pack

≥ 2 years