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ZPCK
CAS No. 26049-94-5
ZPCK( Z-L-Phe chloromethyl ketone | NSC 251810 | SL 01 )
Catalog No. M13792 CAS No. 26049-94-5
ZPCK is a potent, pan autophagy inhibitor, inhibits the cargo degradation inside the vacuole and alters the process of autophagy in mammalian cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameZPCK
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NoteResearch use only, not for human use.
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Brief DescriptionZPCK is a potent, pan autophagy inhibitor, inhibits the cargo degradation inside the vacuole and alters the process of autophagy in mammalian cells.
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DescriptionZPCK (NSC 251810;SL 01) is a potent, pan autophagy inhibitor, inhibits the cargo degradation inside the vacuole and alters the process of autophagy in mammalian cells; also modulates autophagic flux in a novel model plant, Aponogeton madagascariensis.
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In Vitro——
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In Vivo——
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SynonymsZ-L-Phe chloromethyl ketone | NSC 251810 | SL 01
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number26049-94-5
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Formula Weight331.796
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Molecular FormulaC18H18ClNO3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OCC1=CC=CC=C1)N[C@H](C(CCl)=O)CC2=CC=CC=C2
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Chemical NameN-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid, phenylmethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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AMG PERK 44
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) that induces autophagy. It also inhibits GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM), making it useful for cancer research.
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Talarozole
Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM respectively.Talarozole for the treatment of acne psoriasis and other keratinization disorders.
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SMER-28
A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
