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LY2183240

CAS No. 874902-19-9

LY2183240( —— )

Catalog No. M24889 CAS No. 874902-19-9

LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 36 In Stock
25MG 74 In Stock
50MG 141 In Stock
100MG 221 In Stock
200MG 325 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    LY2183240
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).
  • Description
    LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).
  • In Vitro
    ——
  • In Vivo
    LY2183240 (3-30mg/kg; i.p.) dose-dependently attenuates formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms. Animal Model:Male Sprague-Dawley rats (Formalin Pain Model)Dosage:3, 10, 30 mg/kg Administration:I.p.Result:Dose-dependently attenuated formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy|FAAH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    874902-19-9
  • Formula Weight
    307.35
  • Molecular Formula
    C17H17N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (162.68 mM; Need ultrasonic)
  • SMILES
    O=C(N(C)C)N1N=NN=C1CC(C=C2)=CC=C2C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dickason-Chesterfield AK, et al. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):407-23.
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