ML-60218

CAS No. 577784-91-9

ML-60218 ( ML60218 )

Catalog No. M15113 CAS No. 577784-91-9

ML-60218 (ML60218)is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 67 Get Quote
5MG 110 Get Quote
10MG 177 Get Quote
25MG 410 Get Quote
50MG 605 Get Quote
100MG 860 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ML-60218
  • Note
    Research use only, not for human use.
  • Brief Description
    ML-60218 (ML60218)is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
  • Description
    ML-60218 (ML60218)is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively; compromises the structural integrity of viroplasms and rotavirus double-layered particles, interferes with the formation of higher order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize.
  • Synonyms
    ML60218
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    577784-91-9
  • Formula Weight
    452.37
  • Molecular Formula
    C19H15Cl2N3O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=CC=CC=C1Cl)(NC2=CC(C3=C(C)C4=CC(Cl)=CC=C4S3)=NN2C)=O
  • Chemical Name
    2-chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Eichwald C, et al. J Virol. 2017 Nov 15. pii: JVI.01943-17.
2. Wu L, et al. Eukaryot Cell. 2003 Apr;2(2):256-64.
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