ML-60218( ML60218 )

Catalog No. M15113 CAS No. 577784-91-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML-60218
Note

Research use only, not for human use.
Brief Description

ML-60218 (ML60218)?is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
Description

ML-60218 (ML60218)?is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively; compromises the structural integrity of viroplasms and rotavirus double-layered particles, interferes with the formation of higher order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize.
In Vitro

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In Vivo

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Synonyms

ML60218
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

——
Indication

——

CAS Number

577784-91-9
Formula Weight

452.368
Molecular Formula

C19H15Cl2N3O2S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (221.05 mM)
SMILES

O=S(C1=CC=CC=C1Cl)(NC2=CC(C3=C(C)C4=CC(Cl)=CC=C4S3)=NN2C)=O
Chemical Name

2-chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide

1. Eichwald C, et al. J Virol. 2017 Nov 15. pii: JVI.01943-17. 2. Wu L, et al. Eukaryot Cell. 2003 Apr;2(2):256-64.

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