PNR-7-02
CAS No. 1633660-76-0
PNR-7-02 ( PNR-7-02; PNR702; PNR 7 02; PNR-702 )
Catalog No. M12461 CAS No. 1633660-76-0
PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
|
50MG | 1782 | Get Quote |
|
100MG | 2250 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePNR-7-02
-
NoteResearch use only, not for human use.
-
Brief DescriptionPNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
-
DescriptionPNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
-
SynonymsPNR-7-02; PNR702; PNR 7 02; PNR-702
-
PathwayCell Cycle/DNA Damage
-
TargetDNA/RNA Synthesis
-
RecptorDNA/RNA Synthesis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1633660-76-0
-
Formula Weight445.92
-
Molecular FormulaC24H16ClN3O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(/C(C(N1)=O)=C\C2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S
-
Chemical Name5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.
molnova catalog
related products
-
Betrixaban hydrochlo...
Betrixaban is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
-
UNC6852
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
-
Sempervirine
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .