PNR-7-02( PNR-7-02 | PNR702 | PNR 7 02 | PNR-702 )

Catalog No. M12461 CAS No. 1633660-76-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PNR-7-02
Note

Research use only, not for human use.
Brief Description

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
Description

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
In Vitro

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In Vivo

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Synonyms

PNR-7-02 | PNR702 | PNR 7 02 | PNR-702
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

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Indication

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CAS Number

1633660-76-0
Formula Weight

445.921
Molecular Formula

C24H16ClN3O2S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(/C(C(N1)=O)=C\C2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S
Chemical Name

5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.

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