PNR-7-02

CAS No. 1633660-76-0

PNR-7-02 ( PNR-7-02; PNR702; PNR 7 02; PNR-702 )

Catalog No. M12461 CAS No. 1633660-76-0

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    PNR-7-02
  • Note
    Research use only, not for human use.
  • Brief Description
    PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
  • Description
    PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
  • Synonyms
    PNR-7-02; PNR702; PNR 7 02; PNR-702
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1633660-76-0
  • Formula Weight
    445.92
  • Molecular Formula
    C24H16ClN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(/C(C(N1)=O)=C\C2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S
  • Chemical Name
    5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.
molnova catalog
related products
  • Betrixaban hydrochlo...

    Betrixaban is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).

  • UNC6852

    UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.

  • Sempervirine

    Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .