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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - PNR-7-02

PNR-7-02

CAS No. 1633660-76-0

PNR-7-02( PNR-7-02 | PNR702 | PNR 7 02 | PNR-702 )

Catalog No. M12461 CAS No. 1633660-76-0

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PNR-7-02
  • Note
    Research use only, not for human use.
  • Brief Description
    PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM.
  • Description
    PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PNR-7-02 | PNR702 | PNR 7 02 | PNR-702
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1633660-76-0
  • Formula Weight
    445.921
  • Molecular Formula
    C24H16ClN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(/C(C(N1)=O)=C\C2=CN(CC3=CC=C4C=CC=CC4=C3)C5=C2C=C(Cl)C=C5)NC1=S
  • Chemical Name
    5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.
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