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MK6-83

CAS No. 1062271-24-2

MK6-83( MK6 83 | MK683 )

Catalog No. M27779 CAS No. 1062271-24-2

MK6-83 is the transient receptor potential channel ML3 agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK6-83
  • Note
    Research use only, not for human use.
  • Brief Description
    MK6-83 is the transient receptor potential channel ML3 agonist.
  • Description
    MK6-83 is the transient receptor potential channel ML3 agonist.(In Vitro):MK6-83(0.2-30 μM) shows no signs of cytotoxicity. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.
  • In Vitro
    Cell Viability Assay.Cell Line:Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation.Concentration:0-10 μM.Incubation Time:24 h.Result:Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells.
  • In Vivo
    ——
  • Synonyms
    MK6 83 | MK683
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    Akt| mTOR| Microtubule/Tubulin| Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1062271-24-2
  • Formula Weight
    336.47
  • Molecular Formula
    C16H20N2O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (74.30 mM)
  • SMILES
    Cc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jason E Faris,et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.Invest New Drugs. 2012 Aug;30(4):1614-20.
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