MM-401 ( MM 401;MM401 )

Catalog No. M11873 CAS No. 1442106-10-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MM-401
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
Description

A potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM; represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM); specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion; reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.
Synonyms

MM 401;MM401
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1442106-10-6
Formula Weight

586.73
Molecular Formula

C29H46N8O5
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)C(N[C@@]1(C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC)C(N[C@H](C2=CC=CC=C2)C(NCCCC1)=O)=O)=O)=O)=O
Chemical Name

N-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide

1. Cao F, et al. Mol Cell. 2014 Jan 23;53(2):247-61.
2. Zhang H, et al. Cell Stem Cell. 2016 Apr 7;18(4):481-94.

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