MI-223 ( NSC 320223 )

Catalog No. M16518 CAS No. 907166-59-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MI-223
Note

Research use only, not for human use.
Brief Description

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.
Description

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
Synonyms

NSC 320223
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

907166-59-0
Formula Weight

419.87
Molecular Formula

C23H18ClN3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
Chemical Name

2-(2-chlorophenyl)-3-[[(Z)-(5-ethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]quinazolin-4-one

1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.

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