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MI-223

CAS No. 907166-59-0

MI-223( NSC 320223 )

Catalog No. M16518 CAS No. 907166-59-0

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MI-223
  • Note
    Research use only, not for human use.
  • Brief Description
    MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.
  • Description
    MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC 320223
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    907166-59-0
  • Formula Weight
    419.865
  • Molecular Formula
    C23H18ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4
  • Chemical Name
    2-(2-chlorophenyl)-3-[[(Z)-(5-ethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]quinazolin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.
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