Navitoclax-piperazine

CAS No. 2143096-93-7

Navitoclax-piperazine ( ABT-263-piperazine )

Catalog No. M23975 CAS No. 2143096-93-7

Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 292 In Stock
10MG 495 In Stock
25MG 781 In Stock
50MG 1071 In Stock
100MG 1449 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Navitoclax-piperazine
  • Note
    Research use only, not for human use.
  • Brief Description
    Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).
  • Description
    Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).
  • Synonyms
    ABT-263-piperazine
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-xL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2143096-93-7
  • Formula Weight
    973.6
  • Molecular Formula
    C47H56ClF3N6O5S3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL?(256.77 mM;?Need ultrasonic)
  • SMILES
    CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCNCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sajid Khan, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med 25, 1938–1947 (2019).
molnova catalog
related products
  • MI-223

    MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM.

  • S-63845

    S-63845 (S63845)is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM.

  • Bcl-xL antagonist 2

    Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.