CID5721353 ( CID5721353; CID-5721353; CID 5721353; BCL6 Inhibitor )

Catalog No. M13941 CAS No. 301356-95-6

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Product Name

CID5721353
Note

Research use only, not for human use.
Brief Description

BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM.
Description

BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM; binds to a pocket in the lateral groove of the BCL6 BTB domain, specifically inhibits BCL6 but not other BTB-ZF proteins; disrupts BCL6/corepressor complexes and reactivates BCL6 target genes in vitro and in vivo, selectively kills BCL6-dependent DLBCL cells; suppresses human DLBCL xenografts in mice with favorable pharmacokinetics.
Synonyms

CID5721353; CID-5721353; CID 5721353; BCL6 Inhibitor
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-6
Research Area

Cancer
Indication

——

CAS Number

301356-95-6
Formula Weight

457.27
Molecular Formula

C15H9BrN2O6S2
Purity

>98% (HPLC)
Solubility

（ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(O)C(N(C/1=O)C(SC1=C2C(NC3=C/2C=C(Br)C=C3)=O)=S)CC(O)=O
Chemical Name

(Z)-2-(5-(5-bromo-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)succinic acid

1. Cerchietti LC, et al. Cancer Cell. 2010 Apr 13;17(4):400-11.
2. Cardenas MG, et al. J Clin Invest. 2016 Sep 1;126(9):3351-62.

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