HPOB ( —— )

Catalog No. M11815 CAS No. 1429651-50-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

HPOB
Note

Research use only, not for human use.
Brief Description

A potent and selective HDAC6 inhibitor (IC50=56 nM).
Description

A potent and selective HDAC6 inhibitor (IC50=56 nM); shows IC50>1.7 uM for the other HDACs, more potent than tubacin; selectively inhibits HDAC6 catalytic activity in vivo and in vitro; causes growth inhibition of normal and transformed cells but does not induce cell death; enhances the effectiveness of DNA-damaging anticancer drugs in transformed cells but not normal cells.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC1;HDAC10;HDAC3;HDAC6;HDAC8
Research Area

Cancer
Indication

——

CAS Number

1429651-50-2
Formula Weight

314.34
Molecular Formula

C17H18N2O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO
Chemical Name

Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-

1. Lee JH, et al. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9.
2. Li ZY, et al. Neurochem Int. 2016 Oct;99:239-51.

Calculator

molnova catalog