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M435-1279
CAS No. 1359431-16-5
M435-1279( —— )
Catalog No. M37630 CAS No. 1359431-16-5
M435-1279 is a UBE2T inhibitor that blocks UBE2T-mediated degradation of RACK1, thereby inhibiting the hyperactivation of the Wnt/β-catenin signaling pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 83 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 212 | In Stock |
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| 50MG | 310 | In Stock |
|
| 100MG | 437 | In Stock |
|
| 200MG | 616 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameM435-1279
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NoteResearch use only, not for human use.
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Brief DescriptionM435-1279 is a UBE2T inhibitor that blocks UBE2T-mediated degradation of RACK1, thereby inhibiting the hyperactivation of the Wnt/β-catenin signaling pathway.
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DescriptionM435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
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In VitroCell Viability Assay Cell Line:HGC27, AGS, and MKN45 cells Concentration:0, 2, 4, 8, 16, 31 μM Incubation Time:48?h Result:Inhibited the cell growth. Cell Viability Assay Cell Line:HGC27, AGS, and MKN45 cells Concentration:0, 4, 8, 12, 16, 20 μM Incubation Time:Result:Inhibited the cell viability with IC50s of 16.8, 11.88, 6.93, 7.76 μM in GES-1, HGC27, MKN45, AGS cells, respectively.
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In VivoAnimal Model:BALB/C nude mice CDX model (MKN45 tumor size: 75–100?mm3) Dosage:5?mg/kg/day Administration:Intratumor injection for 18 days Result:Slowed the tumor growth.Induced higher RACK1 proteins expression, and lower Ki-67 and β-catenin proteins expression in intratumor tumors.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetE1
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RecptorE1/E2/E3 Enzyme
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Research Area——
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Indication——
Chemical Information
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CAS Number1359431-16-5
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Formula Weight419.47
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Molecular FormulaC18H17N3O5S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (119.20 mM; Ultrasonic )
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SMILESNS(=O)(=O)c1ccc(NC(=O)c2c(O)c3c4CCCCc4sc3[nH]c2=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu Z, et al. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene. 2021 Feb;40(5):1027-1042. doi: 10.1038/s41388-020-01572-w. Epub 2020 Dec 15. Erratum in: Oncogene. 2021 Apr;40(14):2622-2623.?
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