Cyclo(Ile-Val) shows moderate antifungal and weak antitumor activities in vitro.

Norspermine is a polyamine analogue used in the treatment of non-small cell lung carcinoma and breast cancer.

Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.