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INDY
CAS No. 1169755-45-6
INDY( -(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one )
Catalog No. M26718 CAS No. 1169755-45-6
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 56 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 107 | In Stock |
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| 50MG | 150 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameINDY
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NoteResearch use only, not for human use.
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Brief DescriptionINDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
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DescriptionINDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.(In Vitro):INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.(In Vivo):In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.
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In VitroWestern Blot Analysis Cell Line:COS7 cells transfected with either EGFP-Dyrk1A and EGFP-tau Concentration:0.3, 1, 3, 10, 30 μM Incubation Time:20 hours Result:Mildly inhibited tau-phosphorylation at 3 μM, and nearly completely inhibited at 30 μM.
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In Vivo——
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Synonyms-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
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PathwayOthers
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TargetOther Targets
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RecptorGluN1| NMDA receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1169755-45-6
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Formula Weight235.3
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Molecular FormulaC12H13NO2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 33.33 mg/mL (141.65 )
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SMILESCCN1\C(Sc2ccc(O)cc12)=C\C(C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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RO5166017
RO5166017 is an orally active, potent and selective trace amine-associated receptor 1 (TAAR1) agonist for the study of conditioned taste aversion frontal nerve disorders.
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Maltoheptaose
Maltoheptaose is an activator of phosphorylase B for the preparation of heptulose-2-phosphate.
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P110
Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.
