VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.

1-O-Methylemodin is a nature product that could be isolated from Zopfiella longicaudata. 1-O-Methylemodin has antifungal activity.