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13-Oxyingenol dodecanoat
CAS No. 54706-70-6
13-Oxyingenol dodecanoat( ——— )
Catalog No. M38697 CAS No. 54706-70-6
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name13-Oxyingenol dodecanoat
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NoteResearch use only, not for human use.
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Brief Description13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.
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DescriptionDodecanoic acid ingenol ester, a natural compound, shows moderate cytotoxicity with IC50 values being 35.59 μM (Caco-2), 24.04 μM (MCF-7), and 22.24 μM (MCF-7/ADM).
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In VitroCell Viability Assay Cell Line:A549 and H460 cells Concentration:0, 3.125, 6.25, 12.5, 25, and 50 μM Incubation Time:72 h Result:Increased significantly the antitumor activity of A549 and H460 cells.Western Blot Analysis Cell Line:A549 and H460 cells Concentration:0, 5, 10, 20 μM Incubation Time:72 h Result:Induced significant up-regulation of ATG5, degradation of p62, and dose-dependent conversion of LC3 I to LC3 II.
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In VivoAnimal Model:xenograft model by injecting H460 cells into nude mice Dosage:2.5 mg/kg and 5 mg/kg; every two days for two weeks Administration:Intraperitoneal injection (i.p.)Result:nhibited the growth of transplanted tumors in nude mice and had no significant toxic effects on organ function.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area———
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Indication———
Chemical Information
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CAS Number54706-70-6
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Formula Weight546.745
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Molecular FormulaC32H50O7
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu Q, et al. Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. Eur J Med Chem. 2018 Aug 5;156:618-627.?
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