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Epimedokoreanin B
CAS No. 161068-53-7
Epimedokoreanin B( —— )
Catalog No. M37770 CAS No. 161068-53-7
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 417 | In Stock |
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| 5MG | 368 | In Stock |
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| 10MG | 540 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEpimedokoreanin B
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NoteResearch use only, not for human use.
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Brief DescriptionEpimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.
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DescriptionEpimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.
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In VitroCell Cytotoxicity AssayCell Line:A549, Calu1 and H1299 cells Concentration:3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM Incubation Time:48 hours Result:Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.Western Blot Analysis Cell Line:Human monocyte-derived macrophages (HMDMs) Concentration:5 μM Incubation Time:24 hoursResult: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.
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In VivoAnimal Model:Female C3H mice (8-10 weeks old) injected with LM8 cells Dosage:20 mg/kg Administration:Oral administration; thrice a week; for 17 days Result:Inhibited tumor growth.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Antibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number161068-53-7
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Formula Weight422.47
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Molecular FormulaC25H26O6
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Purity>98% (HPLC)
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Solubility——
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SMILESC(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263.?
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